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Synthesis and biological evaluation of colchicine and thiocolchicine derivatives bearing a Michael acceptor moiety in ring A

E. A. Mol’kova,E. S. Shchegravina,V. F. Otvagin, N. S. Kuzmina,Yu. B. Malysheva,E. V. Svirshchevskaya,E. A. Zaburdaeva,A. Yu. Fedorov

Russian Chemical Bulletin（2022）

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关键词
colchicine, thiocolchicine, covalent binding, tubulin, antimitotic activity
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