Pos-411 a novel adrenal peptide that prevents vascular calcification by inhibiting osteogenic transdifferentiation

Vascular calcification is an important component of cardiovascular (CV) pathology that is highly prevalent in the general population, increases with ageing and is associated with increased mortality in patients with hypertension, chronic kidney disease (CKD), and atherosclerosis. The pathogenesis of vascular calcification is complex and involves an imbalance of enhancers and inhibitors of the underlying processes. The adrenal glands participate in CV physiology and the pathophysiology of CV diseases through their effects on sodium and water metabolism, vascular tone and cardiac function.In the present study, we identified a new adrenal compound controlling mesenchymal cell differentiation that regulates osteoblastic differentiation in the context of vascular calcification.