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Phosphorylation of an Ethylene Response Factor by MPK3/MPK6 Mediates Negative Feedback Regulation of Pathogen-Induced Ethylene Biosynthesis in Arabidopsis

Xiaoyang Wang, Huicong Meng, Yuxi Tang, Yashi Zhang,Yunxia He,Jinggeng Zhou,Xiangzong Meng

Journal of Genetics and Genomics(2022)SCI 2区SCI 3区

Shanghai Normal Univ

Cited 12|Views26
Abstract
Plants under pathogen attack produce high levels of the gaseous phytohormone ethylene to induce plant defense responses via the ethylene signaling pathway.The 1-aminocyclopropane-1-carboxylate synthase(ACS)is a critical rate-limiting enzyme of ethylene biosynthesis.Transcriptional and post-translational upregulation of ACS2 and ACS6 by the mitogen-activated protein kinases MPK3 and MPK6 are previ-ously shown to be crucial for pathogen-induced ethylene biosynthesis in Arabidopsis.Here,we report that the fungal pathogen Botrytis cinerea-induced ethylene biosynthesis in Arabidopsis is under the negative feedback regulation by ethylene signaling pathway.The ethylene response factor ERF1A is further found to act downstream of ethylene signaling to negatively regulate the B.cinerea-induced ethylene biosynthesis via indirectly suppressing the expression of ACS2 and ACS6.Interestingly,ERF1A is shown to also upregulate defensin genes directly and therefore promote Arabidopsis resistance to B.cinerea.Further-more,ERF1A is identified to be a substrate of MPK3 and MPK6,which phosphoactivate ERF1A to enhance its functions in suppressing ethylene biosynthesis and inducing defensin gene expression.Taken together,our data reveal that ERF1A and its phosphorylation by MPK3/MPK6 not only mediate the negative-feedback regulation of the B.cinerea-induced ethylene biosynthesis,but also upregulate defensin gene expression to increase Arabidopsis resistance to B.cinerea.
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Key words
Ethylene response factor,Mitogen-activated protein kinase,Protein phosphorylation,Ethylene biosynthesis,Defensin gene induction,Disease resistance
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要点】:研究发现拟南芥中的乙烯反应因子ERF1A通过MPK3/MPK6介导的磷酸化作用,对病原体诱导的乙烯生物合成进行负反馈调节,并增强拟南芥对病原菌的抗性。

方法】:通过研究乙烯信号途径和转录后修饰,揭示ERF1A及其磷酸化在调控乙烯生物合成和防御基因表达中的作用。

实验】:利用真菌病原体Botrytis cinerea处理拟南芥,并分析乙烯生物合成关键酶ACS2和ACS6的表达,发现ERF1A被MPK3/MPK6磷酸化,实验数据基于拟南芥为实验模型。