6‐O‐sulfation of Endothelial Glycocalyx Heparan Sulfates Regulates Systemic Coagulation

Kaori Oshima,Pavel Davizon-Castillo,Giovanny Hernandez,Christine Baird,Marilyn Manco-Johnson,Eric Schmidt

The FASEB journal（2022）

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摘要

The anticoagulant effect of endothelial-surface HS is dependent on 6-O sulfation of its constituent disaccharides, and this effect is mediated by the mechanisms distinct from well-known heparin anticoagulation mechanisms.

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