HHV-8-Associated Multicentric Castleman Disease, a Diagnostic Challenge in a Patient with Acquired Immunodeficiency Syndrome and Fever.
Journal of investigative medicine high impact case reports(2022)
摘要
Patients with acquired immunodeficiency syndrome (AIDS) are at an increased susceptibility to pathogens and associated malignancies which can present with a unique constellation of symptoms. In this article, we describe a case of Castleman disease in a patient with AIDS, nonadherent with antiretroviral therapy (ART), who presented with fevers, constant abdominal pain, nausea, and vomiting. After an extensive work up, a lymph node biopsy confirmed a diagnosis of human herpesvirus-8 (HHV-8)-associated multicentric Castleman disease. Patients presenting with AIDS and fever have broad differential diagnoses; therefore, reaching a diagnosis as rare as Castleman disease can be challenging. HHV-8 has a propensity to CD20 positive B cells, which allows rituximab to be an effect treatment.
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关键词
HHV-8,multicentric Castleman disease,AIDS,immunocompromised,lymphoproliferative
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