Ancestral Library Identifies Conserved Reprogrammable Liver Motif on AAV Capsid

Eric Zinn,Carmen Unzu,Pauline F. Schmit,Heikki T. Turunen,Nerea Zabaleta,Julio Sanmiguel,Allegra Fieldsend,Urja Bhatt,Cheikh Diop,Erin Merkel,Rakesh Gurrala,Bryan Peacker, Christopher Rios,Kathleen Messemer, Jennifer Santos,Reynette Estelien,Eva Andres-Mateos,Amy J. Wagers,Christopher Tipper,Luk H. Vandenberghe

Social Science Research Network（2021）

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adeno-associated virus,gene therapy,capsid,liver toggle,Anc80,hepatotoxicity,AAV9,library,ancestral sequence reconstruction,ASR,hepatotropism

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