GCN 5 L 1 promotes diastolic dysfunction by inhibiting cardiac pyruvate oxidation 1 2

1 Vascular Medicine Institute, 2 Center for Metabolism and Mitochondrial Medicine, Department of 6 Medicine, University of Pittsburgh, Pittsburgh, PA 15261. 3 Biomedical Mass Spectrometry Center, 7 Schools of the Health Sciences, University of Pittsburgh, Pittsburgh, PA 15261. 4 Department of Cell 8 Biology, University of Pittsburgh, Pittsburgh, PA 15261. 5 Department of Chemistry, University of 9 Pittsburgh, Pittsburgh, PA 15261. 10