P478. Functional Characterization of Rare and Protein-Damaging Mutations in Patients with Sporadic Schizophrenia Using CRISPRi in Ipscs
Biological psychiatry（2022）
Abstract
Rare mutations of individually large effect contribute to the genetic architecture of schizophrenia. Functional characterization of these mutations can reveal insights into disease pathobiology.
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Key words
Schizophrenia,Induced Pluripotent Stem Cells (iPSCs),Genetics
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