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Multistationarity in Cyclic Sequestration-Transmutation Networks

Bulletin of Mathematical Biology(2022)

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摘要
We consider a natural class of reaction networks which consist of reactions where either two species can inactivate each other (i.e., sequestration), or some species can be transformed into another (i.e., transmutation), in a way that gives rise to a feedback cycle. We completely characterize the capacity of multistationarity of these networks. This is especially interesting because such networks provide simple examples of "atoms of multistationarity", i.e., minimal networks that can give rise to multiple positive steady states.
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关键词
Reaction networks,Mass-action kinetics,General kinetics,Multistationarity,Sequestration-transmutation networks,Atoms of multistationarity,VEGFR dimerization
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