Novel domino synthesis of 2‐(2,3.4‐substituted phenyl) quinazolin‐4‐amine
Journal of Heterocyclic Chemistry(2022)
Abstract
Convenient domino protocol was developed for the synthesis of 2‐arylquinazolin‐4‐amines by the reaction of N‐(2‐cyanophenyl) substituted benzimidoyl isothiocyanates with isopropyl amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives.
MoreTranslated text
Key words
novel domino synthesis
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined