Clinical evaluation of ayush pe eye drops in the management of acute allergic conjunctivitis: an open label single arm prospective multicenter study

IntroductionOcular allergy is one of the most common prevalent clinical conditions in the world with a rapid increase in the past few years. It has a multifactorial etiology and is a conjunctival inflammatory response due to IgE mediated mast cell activation. The disease is characterized by itching, redness, burning sensation and watering of eyes which go off and on. Due to the side effects of contemporary management, a safe, cost effective user tolerable potent Ayurveda drug AYUSH PE was developed after undergoing all quality assurance tests.Materials and MethodsA multicenter study open labeled single group prospective study was conducted at four research institutes of the Central Council for Research in Ayurvedic Sciences (CCRAS), Ministry of AYUSH from May 2019 to December 2019. A total of 221 participants were enrolled based on purposive sampling at four study sites. The participants were evaluated based on the signs and symptoms of allergic conjunctivitis using the VAS score (0-100). Two drops of AYUSH PE Eye drops were instilled to the affected eyes six times a day and the patients were reviewed after one week. The medicine was then stopped and a second follow up was done again after one more week.ResultsTotal of 217 participants were analyzed for the outcomes. Statistically significant changes was observed in all the assessment parameters viz: itching, redness of eyes, watery discharge, lid swelling, foreign body sensation, liking for warm touches, heaviness in eyes, feeling of stickiness in eyes, appearance of allergic hue in eyes, feeling of excessive cold in eyes and slimy secretions from eyes at 7th day (p-value <0.001) and at 14th day (p-value <0.001) as compared to baseline.ConclusionAYUSH PE drops are safe and effective and user tolerable eye drops in the management of acute allergic conjunctivitis.