Species Differences Between Rats and Primates (humans and Monkeys) in Complex Cleavage Pathways of DS-8500a Characterized by 14C-ADME Studies in Humans and Monkeys after Administration of Two Radiolabeled Compounds and in Vitro Studies.
Drug metabolism and pharmacokinetics（2022）
Key words
Cleavage pathway,Species difference,Metabolic pro filing,Intestinal micro flora,Reductive ring -opening metabolism
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