Human Gain-of-function Variants in HNF1A Confer Protection from Diabetes but Independently Increase Hepatic Secretion of Atherogenic Lipoproteins
openalex（2022）
关键词
HNF1A,PCSK9,ANGPTL3,deep mutational scan,saturation mutagenesis,UK Biobank,gain of function,diabetes,inflammation,atherosclerosis,coronary artery disease
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