EVALUATION OF ENDOTOXEMIA, SOLUBLE CD14 AND IL-1Β IN DOGS WITH INTESTINAL DYSBIOSIS THAT WERE TREATED WITH PROBIOTICS: A PROSPECTIVE STUDY

The aim of this study was to compare the serum endotoxin levels in correlation with soluble CD14 and IL-1 beta in dogs with intestinal dysbiosis that were treated with a probiotic product containing Bacillus subtilis, Bacillus licheniformis and Pediococcus acidilactici. Levels of serum endotoxin, soluble CD14 and IL-1 beta were assessed before meal consumption, and 6 and 12 h after meal consumption, both prior to initiation of probiotic treatment and after completion of 30 days of treatment. Pre-meal serum endotoxin levels decreased by 25.89% and 6 h and 12 h post-meal levels decreased by 35.00% and 44.93%, respectively, when compared to the respective pre-treatment values which correlated with a decrease in serum soluble CD14 levels, while IL-1 beta remained approximatively constant.