Genetic Mapping of Uba3 O.2.2 , a Pupal Lethal Mutation in Drosophila Melanogaster
Elizabeth Mast,Kayla L Bieser,Mary Abraham-Villa,Vanessa Adams,Akinwonuola J Akinlehin,Lynarose Z Aquino,Joseph L Austin,Abigail K Austin,Carissa N Beckham,Ethan J Bengson,Amanda Bieszk,Brianna L Bogard,Rowan C Brennan,Rebecca M Brnot,Nicholas J Cirone,Mason R Clark,Brianna N Cooper,Dennys Cruz,Katlyn A Daprizio,Jason DeBoe,Michaela M Dencker,Laura L Donnelly,Leanne Driscoll,Ryan J DuBeau,Sirada W Durso,Adam Ejub,Waad Elgosbi,Melanie Estrada,Kaeli Evins,Pearl D Fox,Jacob M France,Maira G Franco Hernandez,Lizbeth A Garcia,Olivia Garl,Myeerah R Gorsuch,Mikayla A Gorzeman-Mohr,Madison E Grothouse,Megan E Gubbels,Romina Hakemiamjad,Chloé V Harvey,Madeline A Hoeppner,Jessica L Ivanov,Veronica M Johnson,Jessica L Johnson,Ashton Johnson,Kaleigh Johnston,Katie R Keller,Breanna T Kennedy,Levi R Killian,Marissa Klumb,Olivia L Koehn,Aaron S Koym,Kari J Kress,Regan E Landis,Kaitlyn N Lewis,Enosh Lim,Ilcen K Lopez,D'Artagnan Lowe,Paula Luengo Carretero,Grace Lunaburg,Samantha L Mallinder,Natalie A Marshall,Jessica Mathew,Jasmine Mathew,Hailee S Mcmanaway,Emily N Meegan,Jacob D Meyst,Meredith J Miller,Colin K Minogue,Alina A Mohr,Cristhian I Moran,Adrian Moran,Morgan D Morris,Michael D Morrison,Emmily A Moses,Cade J Mullins,Citlalli I Neri,Jess M Nichols,Breanna R Nickels,Akosua M Okai,Chiedu Okonmah,Makena Paramo,Meagan Paramo,Sydney L Parker,Neil K Parmar,Jacob Paschal,Prem Patel,Deep Patel,Erica B Perkins,Madelyn M Perry,Zachary Perry,Amanda A Pollock,Oxxyris Portalatin,Kamron S Proffitt,Jason T Queen,Alexis C Quemeneur,Amelia G Richardson,Kaylee Rosenberger,Allison M Rutherford,Itchel X Santos-Perez,Christy Y Sarti,Lacey J Schouweiler,Lauren M Sessing,Sara O Setaro,Christopher F Silvestri,Olivia A Smith,Mackenzie J Smith,Jayson C Sumner,Rachel R Sutton,Lindsay Sweckard,Nicholas B Talbott,Peyton A Traxler,Jenna Truesdell,Aaron F Valenti,Leif Verace,Pragathi Vijayakumar,William L Wadley,Katherine E Walter,Ayanna R Williams,Trey J Wilson,Makayla A Witbeck,Trinity M Wobler,Lucas J Wright,Karolina A Zuczkowska,Olivier Devergne,Danielle R Hamill,Hemin P Shah,Jamie Siders,Elizabeth E Taylor,Alysia D Vrailas-Mortimer,Jacob D Kagey
PubMed（2022）
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摘要
An EMS mutagenesis screen was conducted in Drosophila melanogaster to identify growth control mutants. The multiinstitution Fly-CURE consortium phenotypically characterized the O.2.2 mutant using the FLP/FRT system which displayed a mutant lethal phenotype with reduced head development, and darkened ocular tissue. Complementation mapping was conducted to identify the affected gene. A failure to complement was identified in Uba3, resulting in the identification of the novel allele, Uba3O.2.2. Uba3 is a known disruptor of the cell cycle and our data are consistent with early larval/embryonic lethality displayed in numerous species. 3/18/2022 Open Access
