Evaluation of the Relationship Between Eosinophil to Monocyte Ratio and Ieft Ventricle Ejection Fraction in Patients with Acute Coronary Syndrome

INTRODUCTION: Biomarkers have an important role in acute coronary syndromes.Various biomarkers,especially neutrophil to lymphocyte ratio,have been used to determine mortality in acute coronary syndrome.Eosinophil to monocyte ratio,which is also an inflammatory marker,has been evaluated in acute ischemic stroke,and in many cardiovascular diseases;its prognostic impact has been validated.We aimed to investigate the relationship between eosinophil to monocyte ratio and ejection fraction in acute coronary syndrome. METHODS: 210 patients who underwent coronary revascularization were enrolled.Complete blood count,fasting blood glucose,creatinine,Troponin I,total cholesterol,low-density lipoprotein,high-density lipoprotein,triglyceride measurements were done.Transthoracic echocardiography and coronary angiography were performed.The patients with at least one ≥70% coronary stenosis were included. RESULTS: 149(70.9 %) Non-ST elevated and 61(29.1 %) ST elevated myocardial infarction patients were analysed.In ST elevated myocardial infarction group,eosinophil to monocyte ratio,hemoglobin,and ejection fraction were lower;low-density lipoprotein,C-reactive protein,and Troponin were higher.Eosinophil to monocyte ratio was significantly higher in Non-ST elevated group than in the ST elevated group,and increased eosinophil to monocyte ratio was correlated with an increase in left ventricle ejection fraction in multiple linear regression analysis.The partial plot showed an association between eosinophil to monocyte ratio and ejection fraction.Until eosinophil to monocyte ratio increases to 0.2 level,ejection fraction increases;upper than 0.2 no effect of eosinophil to monocyte ratio on ejection fraction was detected.The correlation between eosinophil to monocyte ratio and Troponin was significant. DISCUSSION AND CONCLUSION: Eosinophil to monocyte ratio might predict left ventricle ejection fraction on admission and because of the prognostic role of left ventricle ejection fraction,eosinophil to monocyte ratio also may be a predictor of worse outcomes in acute coronary syndrome.