Abstract P124: JDQ443, a Covalent Irreversible Inhibitor of KRAS G12C, Exhibits a Novel Binding Mode and Demonstrates Potent Anti-Tumor Activity and Favorable Pharmacokinetic Properties in Preclinical ModelsSaskia M. Brachmann,Andreas Weiss,Daniel A. Guthy,Kim Beyer,Johannes Voshol,Michel Maira,Anirudh Prahallad,Diana Graus Porta,Christian Schnell,Nils Ostermann,Andrea Vaupel,Marc Gerspacher,Catherine Leblanc,Dirk Erdmann,Dario Sterker,Grainne Kerr,Giovannoni Jerome,Victoria Head,Rowan Stringer,Ruben De Kanter, Kearns Jeff,Danielle Roman,Toni Widmer,Peter Wessels,Eloisa Jimenez Nunez,Richard Sedrani,Frederic Zecri,Francesco Hofmann,Jeff Engleman,Edwige Lorthiois,Simona CotestaMOLECULAR CANCER THERAPEUTICS(2021)引用 7|浏览0暂无评分关键词Cancer TherapyAI 理解论文溯源树样例生成溯源树,研究论文发展脉络Chat Paper正在生成论文摘要