A Single-Molecular Ruthenium(ii) Complex-Based NIR-II Fluorophore for Enhanced Chemo-Photothermal Therapy

Qianqian Li,Yishen Liu,Bingshan Zhao,Jiapeng Lei,Siyu Lu,Wanxia Gong,Ke Liang,Junzhu Wu,Xuechuan Hong,Yuling Xiao

Chemical communications（2022）

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摘要

Novel NIR-II Ru(II) polypyridyl fluorophore Ru-1 dots for synergistic chemo-photothermal therapy against 4T1 tumors were designed and synthesized. Guided by in vivo NIR-II fluorescence imaging, the synergistic therapeutic efficacy, intracellular delivery, and biodistribution of the Ru-1 dots were precisely tracked in real-time.

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