Browning Markers in Adult Indigenous Residents of Yakutia in Conditions of Natural Cold
Yakut Medical Journal（2021）
Yakutsk Sci Ctr Complex Med Problems | Polytech Univ Marche
Abstract
In this work, the expression profile of markers of brown adipose tissue activity (CIDEA, PRDM 16), markers of browning of white adipocytes (HOXC9, Slc27A1) and marker of beta-oxidation of fatty acids (Cpt1a) in 150 indigenous residents of Yakutia, miners of a diamond mining company, who were exposed to natural cold for 3 months, was analyzed in peripheral blood mononuclear cells. To determine the metabolic status, anthropometric data, glucose level and blood lipid profile of the subjects were evaluated.
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Key words
brown adipose tissue,cold,thermogenesis,browning,Yakutia,obesity
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