MP08-16 NOVEL BIOMATERIAL FOR SLOW-RELEASE DRUG DELIVERY TO THE URETHRA

You have accessJournal of UrologyCME1 May 2022MP08-16 NOVEL BIOMATERIAL FOR SLOW-RELEASE DRUG DELIVERY TO THE URETHRA Courtney K. Rowe, Christopher Foster, Wei Ruan, and Kelly A. Burke Courtney K. RoweCourtney K. Rowe More articles by this author , Christopher FosterChristopher Foster More articles by this author , Wei RuanWei Ruan More articles by this author , and Kelly A. BurkeKelly A. Burke More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002530.16AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Urethral healing after surgery or injury is plagued by strictures and fistulas, impacting quality of life and leading to significant medical costs. A variety of growth factors (GFs) have shown promise in animal studies as a therapeutic approach, but without technology to deliver them to the human urethra they are unable to be used clinically. We hypothesize that a novel biomaterial can be developed to deliver slow-release growth factors and other drugs to the urethra to improve healing after surgery or injury. METHODS: A previously described biocompatible thermoplastic polyurethane (TPU) elastomer was selected as the base material to prepare stents. Silk microspheres were chosen to provide drug delivery given their successful use for slow-release of growth factor and other drugs. RESULTS: The TPU elastomer was modified to replicate the stiffness of silicone urethral stents currently used for hypospadias repair. Silk microspheres were successfully attached and confirmed using scanning electron microscopy (Figure 1). Cell viability studies showed no significant impact on cellular growth from leachable components, confirming a non-toxic material (Figure 2). Loading and release showed sustained slow-release of negatively charged fluorescein-labeled large molecule dye (FITC-DEAE-Dextran, Figure 3). Release of positively charged dye (FITC-CM-Dextran) was the same between TPU alone and TPU with silk microspheres. CONCLUSIONS: Our modified TPU with silk microspheres is capable of successfully providing slow-release drug delivery and is particularly well suited to release negatively charged GFs. Further in vivo and in vitro studies will determine whether urethral healing can be improved with slow-release GFs, or whether delivery of other drugs may be beneficial for patients. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e131 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Courtney K. Rowe More articles by this author Christopher Foster More articles by this author Wei Ruan More articles by this author Kelly A. Burke More articles by this author Expand All Advertisement PDF downloadLoading ...