Cytotoxic Polyprenylated Benzoylphloroglucinol Derivatives from the Branches of Garcinia Schomburgkiana
Planta medica(2022)
摘要
Five undescribed polyprenylated benzoylphloroglucinol derivatives ( 1 - 5 ), named garschomcinols A - E, and five known analogues ( 6 - 10 ) were isolated from the branches of Garcinia schomburgkiana . Their structures were determined on the basis of 1D and 2D NMR and HRESIMS analyses. The absolute configuration of the bicyclo [3.3.1]nonane core structure of the polyprenylated benzoylphloroglucinols was assigned by comparison of its experimental electronic circular dichroism data with that of related compounds. All isolated compounds were evaluated for their cytotoxicity in vitro against five cancer cell lines. Compound 6 showed potent cytotoxicity against five cancer cell lines including KB, HeLa S3, HT-29, MCF-7, and Hep G2 with IC (50) values in the range of 5.05 - 7.03 mu M.
更多查看译文
关键词
Garcinia schomburgkiana,Clusiaceae,polyprenylated benzoylphloroglucinols,garschomcinols A - E,cytotoxicity
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要