Peripheral lymphocyte subset counts predict antibody response after SARS-CoV-2 mRNA-BNT162b2 vaccine in cancer patients: Results from the Vax-On-Profile study

Fabrizio Nelli,Agnese Fabbri,Valentina Panichi,Diana Giannarelli,Giuseppe Topini,Julio R Giron Berrios,Antonella Virtuoso,Eleonora Marrucci,Marco Mazzotta,Marta Schirripa,Carlo Signorelli,Mario G Chilelli,Francesca Primi,Maria A Silvestri,Enzo M Ruggeri

International Immunopharmacology（2022）

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摘要

•ROC curve analysis indicated T helper and B cells useful in predicting seroconversion.•T helper and B cells showed positive linear correlation with anti-RBD-S1 IgG titers.•High-level T and B cells resulted in improved antibody or seroconversion response.•Multivariate testing confirmed negative interaction with low-level T helper and B cell.•Our results may identify high-risk recipients among actively treated cancer patients.

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关键词

COVID-19,SARS-CoV-2 vaccine,Cancer,T helper cell,B cell,Antibody response

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