Straightforward synthesis of bench-stable heteroatom-centered difluoromethylated entities via controlled nucleophilic transfer from activated TMSCHF2
Chemical Communications(2022)
摘要
The commercially available and experimentally convenient (bp 65 degrees C) difluoromethyltrimethylsilane (TMSCHF2) is proposed as a valuable difluoromethylating transfer reagent for delivering the CHF2 moiety to various heteroatom-based electrophiles. Upon activation with an alkoxide, a conceptually intuitive nucleophilic displacement directly furnishes in high yields the bench-stable analogues.
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关键词
nucleophilic transfer,straightforward synthesis,bench-stable,heteroatom-centered
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