Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain
Bioorganic & Medicinal Chemistry（2022）
关键词
Nav1.7,CIP,SCN9A,VGSC,SAR,hERG,FRET,MIA-OA,HEK,CNS,PK,Clint,u,F,TFA,HATU,TBTU,DMSO,DRG,LMA,SNL
AI 理解论文
溯源树
样例
生成溯源树，研究论文发展脉络
Chat Paper
正在生成论文摘要