Neuropathologic damage induced by radiofrequency ablation at different temperatures

•There is a positive correlation between temperature and neuropathological damage caused by RFA at different temperatures.•There is a positive correlation between nerve conduction velocity and temperature.•Nerve injury occurs when the temperature reaches 67°C, and the main pathogenesis is closely related to the expression of SCN9A, SCN3B and NFASC protein in sciatic nerve tissue caused by heat transfer injury.