Liquid chromatography-tandem mass spectrometry based quantification of arginine metabolites including polyamines in different sample matrices

•Derivatization-free HILIC-MS/MS for arginine metabolites including polyamines.•Quantification of amines including spermidine, spermine and acetylated metabolites.•Application in cell culture systems, tissues and organs of different origins.•Metabolites related to biological processes including aging and age-related diseases.•Biomarkers to assess severity of neurodegenerative and metabolic diseases.