Digital image analysis of intraepithelial B-lymphocytes to assess lymphoepithelial lesions in salivary glands of Sjögren's syndrome patients.

Martha S van Ginkel,Tineke van der Sluis,Marian L C Bulthuis,Henk J Buikema,Erlin A Haacke,Suzanne Arends, Stine Harder,Fred K L Spijkervet,Hendrika Bootsma,Arjan Vissink,Frans G M Kroese,Bert van der Vegt

Rheumatology (Oxford, England)（2022）

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摘要

The presence of intraepithelial B-lymphocytes in salivary gland biopsies of sicca patients is a clear indicator of pSS and can be used as an objective alternative to LEL scoring. Therefore, identification of B-lymphocyte-containing ducts should be added to the diagnostic histopathological work-up of patients suspected of pSS.

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关键词

SS,histopathology,labial gland,lymphoepithelial lesions,parotid gland,salivary gland

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