Discovery of evodiamine derivatives as potent insecticide candidates

Jingbo Liu,Yabing Shi,Shuting Chen,Fengyun Li,Wen Wen,Yuanhong Wang

Bioorganic & Medicinal Chemistry（2022）

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Abstract
Evodiamine derivative 3z exhibited excellent larvicidal activities against M. separata, P. xylostella and H. armigera, and could act on the ryanodine receptor of M. separata.
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Key words
Evodiamine,Insecticidal activity,Structure activity relationships,Mode of action
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