Extension of hydrogen borrowing alkylation reactions for the total synthesis of (−)-γ-lycorane
Chemical Communications(2022)
摘要
The total synthesis of (–)-γ-lycorane (10 steps) and synthesis of (±)-γ-lycorane (8 steps) was completed from cyclohexenone. A new two step hydrogen borrowing alkylation of an aziridinyl alcohol, coupled with a Ph* (Me5C6) deprotection/cyclisation procedure was developed for de novo formation of the fused 6,5 heterocyclic ring. This work is one of the first examples of hydrogen borrowing C–C bond formation being used as a key step in a total synthesis project.
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关键词
hydrogen borrowing alkylation reactions,total synthesis
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