Elexacaftor/tezacaftor/ivacaftor Outpatient Desensitization

Ramya Balijepally, Denise Kwong,Linda Zhu, Juanita Valdes Camacho,Anne Liu

Annals of Allergy Asthma & Immunology（2021）SCI 2区SCI 3区

Stanford Univ | Stanford Hlth Care

Cited 6|Views1

Abstract

Delayed hypersensitivity reactions characterized by rashes occur in patients taking elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA, Trikafta, Vertex Pharmaceuticals, Boston, Massachusetts), a cystic fibrosis transmembrane conductance regulator (CFTR) modulator. ELX/TEZ/IVA was approved in 2019 for patients with cystic fibrosis (CF) greater than or equal to 12 years who carry the Phe508del mutation on at least 1 allele. 1 Middleton PG Mall MA Drevinek P et al. Elexacaftor-tezacaftor-ivacaftor for cystic fibrosis with a single Phe508del allele. N Eng J Med. 2019; 381: 1809-1819 Google Scholar Both ELX and TEZ increase expression of the CFTR protein, 1 Middleton PG Mall MA Drevinek P et al. Elexacaftor-tezacaftor-ivacaftor for cystic fibrosis with a single Phe508del allele. N Eng J Med. 2019; 381: 1809-1819 Google Scholar whereas IVA enhances CFTR channel gating. 1 Middleton PG Mall MA Drevinek P et al. Elexacaftor-tezacaftor-ivacaftor for cystic fibrosis with a single Phe508del allele. N Eng J Med. 2019; 381: 1809-1819 Google Scholar

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