FKS1 is Required for Cryptococcus Neoformans Fitness in Vivo : Application of Copper-Regulated Gene Expression to Mouse Models of Cryptococcosis
mSphere(2022)
摘要
Conditional expression systems are widely used to genetically validate antifungal drug targets in mouse models of infection. Copper-regulated expression using the promoter of the CTR4 gene has been sporadically used for this purpose in C. neoformans .
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关键词
Cryptococcus neoformans,echinocandins,essential genes,glucan synthase
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