Discovery and pharmacological characterization of cetrelimab (JNJ-63723283), an anti–programmed cell death protein-1 (PD-1) antibody, in human cancer models

Nikki DeAngelis,Catherine Ferrante,Gordon Powers,Jocelyn Sendecki,Bethany Mattson,Darlene Pizutti,Kathryn Packman,Weirong Wang,Kevin Trouba,Rupesh Nanjunda,John Wheeler, Ray Brittingham,Sheng-Jiun Wu,Jinquan Luo,Matthew V. Lorenzi,Raluca I. Verona

Cancer Chemotherapy and Pharmacology（2022）

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关键词
Immune checkpoint inhibitor,Programmed cell death protein-1,T cell function,Antitumor activity,Toxicokinetic assessment
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