Recommended Antibiotic Dosage Regimens in Critically Ill Patients with Augmented Renal Clearance: A Systematic Review

Catarina Mendes Silva,João Pedro Baptista, Iolanda Santos,Paulo Martins

International Journal of Antimicrobial Agents（2022）

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摘要

•Achieving optimal antibiotic dosing in the critically ill can be challenging•Augmented renal clearance is associated with subtherapeutic plasma concentrations of antibiotics•Dosage recommendations were found for 18 different antibiotics administered to critically ill patients with augmented renal clearance•Incremental dose adjustment was frequently needed to achieve the desired PK/PD targets

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关键词

Antibiotic,Augmented renal clearance,Critically ill,Dosing,Pharmacodynamics,Pharmacokinetics

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