Examination of the Dead Volume in Different COVID-19 Vaccine Tozinameran Delivery Systems

Tozinameran, a vaccine that is approved for COVID-19, is expected to be effective in preventing COVID-19 infection. The objective of this study was to measure the dead space volumes in 250 tozinameran vials used between April 15 and May 25, 2021. Our results revealed that the weight of liquid that can actually be collected from 1 vial is 2241.19 ± 31.24 mg. The weight of liquid required to provide a 0.3 mL dose is 391.88 ± 10.43 mg (in a vaccination syringe and 25G needle), 389.96 ± 10.81 mg (in a tuberculin syringe and 25G needle), 351.81 ± 7.71 mg (in a loaded syringe [gasket protrusion type] and 25G needle), 343.87 ± 10.78 mg (in a vaccination syringe and 25G loaded needle), and 307.46±3.04 mg (in a loaded injector [needle integrated type]). To use the limited amounts of vaccine available most efficiently, it is important to reduce the proportion of vaccine that is discarded. We hope that our results will contribute to preventing the spread of COVID-19.