A Ag₂CO₃/TFA-catalyzed intramolecular annulation approach to imidazo[1,2-c][1,3]oxazin-5-one derivatives

Abdelkarim El Qami,Badr Jismy,Mohamed Akssira,Johan Jacquemin,Abdellatif Tikad,Mohamed Abarbri

Organic & Biomolecular Chemistry（2022）

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摘要

A series of 2,7-disubstituted 3-methylimidazo[1,2-c][1,3]oxazin-5-ones were synthesized in good yields via Ag2CO3/TFA-mediated intramolecular annulation of N-Boc-2-alkynyl-4-bromo(alkynyl)-5-methylimidazoles.

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A Ag2CO3/TFA-catalyzed intramolecular annulation approach to imidazo[1,2-c][1,3]oxazin-5-one derivatives

A Ag₂CO₃/TFA-catalyzed intramolecular annulation approach to imidazo[1,2-c][1,3]oxazin-5-one derivatives