Synthesis of Benzo[d]isothiazoles: an Update

An overview of the recent advancements in the synthesis of benzo[d]isothiazoles is provided. The synthetic approaches developed between 2010 and October 2023 are discussed and arranged in five categories according to the substrate used for the scaffold assembly. The novel synthetic methodologies contribute to the enlargement of the chemical space occupied by benzo[d]isothiazoles and to the exploration of its applications in various fields such as medicinal chemistry and catalysis.