Discovery of Novel Spiro Compound As RAF Kinase Inhibitor with in Vitro Potency Against KRAS Mutant Cancer

Peng Zhao,Xiangzhu Wang,Linghang Zhuang,Song Huang,Yu Zhou,Yuna Yan,Ru Shen,Fan Zhang, Jie Li,Qiyue Hu,Suxing Liu,Rumin Zhang,Ping Dong,Hong Wan,Chang Bai,Feng He,Weikang Tao

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2022）

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RAF,RAS,Mutation,Paradoxical activation,Kinase inhibitor,Spiro compound

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