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The Quest for the Holy Grail in Antithrombotic Therapy: Revitalized Hope for Platelet GPVI As a Safe and Effective Antithrombotic Target

European heart journal(2024)

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  • Pretraining has recently greatly promoted the development of natural language processing (NLP)
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要点】:研究揭示了DRP-104作为一种广谱谷氨酰胺代谢抑制剂,在PD-1或奥西替尼治疗抵抗的代谢旺盛肺癌中具有抗肿瘤活性。

方法】:通过结合PET成像、代谢组学分析和遗传工程小鼠模型(GEMMs)及患者来源的异种移植模型(PDX),研究DRP-104对谷氨酰胺代谢的影响及其在肺癌治疗中的作用。

实验】:在Lkb1-/-;Pten-/-;P53-/- GEMMs和PDX模型中测试了DRP-104单药或与PD-1抑制剂联合使用的疗效,发现DRP-104能显著抑制肿瘤进展,并在OSI抵抗的EGFR突变肺腺癌PDX模型中诱导显著反应。