Infection Polygenic Factors Account for a Small Proportion of the Relationship Between Infections and Mental Disorders

John R. Shorter,Joeri Meijsen,Ron Nudel,Morten Krebs,Jesper Gådin,Dorte H. Mikkelsen,Raquel Nogueira Avelar e Silva,Michael E. Benros,Wesley K. Thompson,Andrés Ingason,Thomas Werge

Biological Psychiatry（2022）

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摘要

Infections and mental disorders share a modest genetic architecture. Infection PRSs can predict risk of certain mental disorders; however, this effect is moderate. Finally, recorded infections partially explain the relationship between infection PRSs and mental disorders.

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关键词

Concordance index,Genetic correlation,iPSYCH,Mediation analysis,Pleiotropy,Polygenic risk score

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