Genomic analysis of paired IDHwt glioblastomas reveals recurrent alterations of MPDZ at relapse after radiotherapy and chemotherapy

Brice Chanez,Romain Appay,Arnaud Guille,Arnaud Lagarde,Carole Colin,José Adelaide,Emilie Denicolai,Carine Jiguet-Jiglaire,Céline Bequet,Thomas Graillon,Sébastien Boissonneau,Isabelle Nanni-Metellus,Henry Dufour,Dominique Figarella-Branger,Olivier Chinot,Emeline Tabouret

Journal of the Neurological Sciences（2022）

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摘要

•MPDZ alterations are increasing at relapse after radio-chemotherapy in IDHwt glioblastoma.•MPDZ alterations could lead glioblastoma aggressiveness and therapeutic resistance.•MPDZ alterations are associated with pejorative outcome.

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关键词

Glioblastoma,Relapse,Paired,MPDZ,Comparative genomic hybridization array,Next generation sequencing

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