SINGLE NUCLEOTIDE POLYMORPHISM –308 G/A OF TUMOR NECROSIS FACTOR-ALPHA (TNF) GENE IN TYPE 2 DIABETES MELLITUS PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASESE
Problemi endokrinnoï patologìï(2015)
摘要
Single nucleotide polymorphism in the promoter region –308 G/A of tumor necrosis factoralpha gene (TNF) in type 2 diabetes mellitus patients (n = 118) and healthy habitants of Kharkiv (n = 50) was studied. There were no significant differences in allele frequencies for single nucleotide polymorphism –308 G/A in patients with type 2 diabetes (pG = 0.861, qA = 0.157), patients with type 2 diabetes in the presence of fatty liver disease (pG = 0.873, qA = 0.127) and healthy individuals (pG = 0.930, qA = 0.070). According to our data the contribution of genetic components in the predisposition to the formation of non-alcoholic fatty liver disease in individuals with diabetes on single nucleotide polymorphism –308 G/A TNF gene was not identified. The obtained data have proved promising for further research, which should be based on a study of the role other candidate genes in the development of nonalcoholic fatty liver disease and their relationship to various metabolic parameters, which will clarify the role of genes in the formation of disease.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要