Estabilidad a largo plazo del trastuzumab en plasma y suero almacenados bajo diferentes condiciones

Objective: The present work analyzed the stability of trastuzumab  concentrations in blood and plasma samples stored at 4 °C and –20 °C. Method: Blood samples of patients treated with trastuzumab (Herceptin ®)  were analyzed. Stability of trastuzumab was analyzed under different conditions: whole blood stored at 4 °C during 72 hours, blood  plasma stored at 4 °C during 120 hours and blood plasma stored at –20 °C during 365 days. Results: In whole blood trastuzumab concentration at 72 hours was 99.01 ± 0.02%, and in plasma samples at 120 hours it was 98.6 ± 2.0%. The  concentration of trastuzumab was 95.22 ± 3.20% after 12 months’ storage  at –20 oC. Conclusions: The concentration of trastuzumab remains stable for at least  72 hours in whole blood stored at 4 °C, five days in plasma stored at 4 °C  and one year in plasma stored at –20 °C.