Post-liver Transplantation GVHD: Time to Consider Histocompatibility Testing

The development of Graft-Versus-Host Disease (GVHD) post-liver transplantation (LT) is an uncommon complication. GVHD occurs when immunocompetent donor lymphocytes originating from the transplanted liver mount a destructive immune response against the immunocompromised recipient. Diagnosis of post-LT GVHD represents a major challenge due to lack of standard criteria a rarity of the condition. Therefore, diagnosis and initiation of therapy are often delayed.