OCT4, Ki-67 and VEGF As Prognostic Factors in Endometrial Carcinoma and Their Role in the Differentiation Between Atypical Endometrial Hyperplasia and Grade 1 Endometrial Carcinoma: an Immunohistochemical Study

: Endometrial carcinoma develops through preliminary stages of endometrial hyperplasia. A population of epithelial stem cells was identified in the human endometrium, these cells may serve as a source of putative endometrial carcinoma. The most important member of cancer stem cell markers is OCT-4. Both tumor cell proliferation (Ki-67) and angiogenesis seem to be important for the development of aggressive tumors.