СПЕРМАТ ОГЕННЫЙ ЦИКЛ У ПОТОМСТВА САМОК КРЫС С ЭКСПЕРИМЕНТАЛЬНЫМ САХАРНЫМ ДИАБЕТОМ 1-ГО ТИПА В РАННИЙ НЕОНАТАЛЬНЫЙ ПЕРИОД

Diabetes mellitus is one of the actual medical and social problems of modern society. Its growth is observed everywhere and acquires the features of an epidemic that covers most countries of the world. According to the WHO, there are currently about 200 million people with diabetes in the world. However, there is no doubt that diabetes affects many organs and life support systems. The role of the mother’s diabetes in the violation of the morphogenesis of various organs and systems of the posterity is still not clear. In this regard, the purpose of this research was to analyze the characteristics of the spermatogenic cycle of the posterity of female rats with experimental type 1th diabetes in the early neonatal period. The object of the research was the posterity of female rats with experimental type 1th diabetes in the early neonatal period (on the first day after birth). Diabetes was modeled in adult mature female rats according to the technique using streptozotocin. An analysis of the results allows us to state that posterity of mothers with experimental type 1th diabetes have a violation of the spermatogenic cycle, which is manifested in reducing the weight parameters of the sex gland, reducing the area of the parenchyma and increasing the area of the stroma, reducing the area of the seminiferous tubules, the total number of spermatogenic cells and their subpopulation composition and, as a result, a decrease in the spermatogenesis index, as well as a decrease in the cell index. It is the ratio of the total number of spermatogenic cells to the number of sustentocytes. Thus, the results indicate that the rat’s offspring with reduced start of health including reproductive is born in female rats with experimental type 1th of the diabetes mellitus.