Circadian Rhythm of Heart Rate Assessed by Wearable Devices Tends to Correlate with the Circadian Rhythm of Salivary Cortisol Concentration in Healthy Young Adults

Objective The objective of this study was to determine whether the circadian rhythm of heart rate or step count using wearable devices was related to that of the salivary cortisol levels and to test the possibility that the data from wearable devices could be used as an indicator of circadian rhythm misalignment, which is emerging as a cause of insomnia and mood disorders. Methods The heart rate and step count were continuously measured in 12 healthy young adults using wearable wrist devices for 5 days, and saliva was sampled every 4 hours, excluding sleeping time, for a total of 48 hours to measure the circadian rhythm of salivary cortisol concentration. Cortisol concentrations were assessed using the enzyme-linked immunosorbent assay. The cosinor analysis for the three measurements, salivary cortisol concentrations, heart rate, and step count, was used to estimate the circadian rhythm. Results The mean values of the acrophase of the cosine-fitted curve of cortisol, heart rate, and step count were 9.06, 15.84, and 19.09, respectively, while those of the amplitude were 7.70, 12.60, and 10.68, respectively. In addition, the mean values of the mesor of the cosine-fitted curve for cortisol, heart rate, and step count were 17.19, 73.55, and 45.45, respectively, and those of robustness were 0.82, 0.56, and 0.18, respectively. There was a possible positive correlation between the acrophase of the cosine-fitted curve of salivary cortisol and that of heart rate (r=0.55, p=0.064). However, there was no correlation between the acrophase of the cosine-fitted curve of salivary cortisol and that of step count (r=-0.2, p=0.533). Conclusion The findings suggest that the heart rate measured using the wearable activity tracker was a relatively reliable biomarker of circadian rhythm. Keywords: Circadian rhythm; Cortisol; Heart rate; Wearable activity tracker