Synergistic Chemotherapy: Bioengineered Dual‐Targeting Protein Nanocage for Stereoscopical Loading of Synergistic Hydrophilic/Hydrophobic Drugs to Enhance Anticancer Efficacy (adv. Funct. Mater. 29/2021)

In article number 2102004, Xiyun Yan, Kelong Fan, and co-workers present an amphiphilic multi-drug loading protein nanocage (Am-PNCage) with a dual-tumor targeting (CD71 and Integrin) property, which exhibits a spatiotemporally programmed cascade drug release pattern and kills drug-resistant tumor cells synergistically. It represents a novel promising protein cage nanocarrier platform for co-loading synergistic hydrophilic and hydrophobic drug pairs and targeted combination chemotherapy.