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Robust Pharmacodynamic Effect of LY3202626, a Central Nervous System Penetrant, Low Dose BACE1 Inhibitor, in Humans and Nonclinical Species

Brian A Willis,Stephen L Lowe,Scott A Monk,Patrick J Cocke,Christopher D Aluise,Leonard N Boggs,Anthony R Borders,Richard A Brier,Robert A Dean,Steven J Green, Douglas E James,Stanford S Jhee,Qun Lin,Albert C Lo,Patrick C May,Brian M Watson,Leonard L Winneroski,Zhixiang Yang,Jennifer A Zimmer,David L McKinzie,Dustin J Mergott

JOURNAL OF ALZHEIMERS DISEASE REPORTS（2022）

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关键词
Amyloid-beta, BACE1 inhibitor, pharmacodynamics, pharmacokinetics, translational studies
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