New Agonist of Adenosine Receptor (Lassbio-1027) Improves Cardiac Remodeling Induced by Myocardial Infarction

GISELE ZAPATA-SUDO,Jaqueline S. da Silva, Fabricio Beltrame,Tadeu L. Montagnoli, Leticia M. Barbosa,Luiza V. Mendes,Valeria M. Cunha,Rodolfo C. Maia,Carlos A. Fraga,Roberto T. Sudo

Nihon Yakuri Gakkai nenkai yoshishu（2018）

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摘要

Introduction: Prevention of cardiac remodeling induced by myocardial infarction (MI) is of great importance because it is one of the factors for the development of heart failure (HF). Thus, LASSBio-1027 was tested in acute model of MI due to its vasodilatory and anti-proliferative profile through the activation of adenosine A2A and A3 receptors.

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