Metastatic Infection by Methicillin-Sensitive Staphylococcus Aureus and Its Potential Association to an Unusual Humoral Immunodeficiency

Multifocal metastatic infection byStaphylococcus aureus is severe and uncommon.We describe the case of a previously asymptomatic 63-year-old man diagnosed with complicated staphylococcal endocarditis of the mitral valve along with cervical and lumbar spondylodiscitis, and multiple pre/para-vertebral abscesses; establishing a persistent flaccid tetraparesis, neurogenic bladder and anal sphincter dysfunction.The patient overcame infection after an 8-week Cloxacillin/ Rifampicin treatment associated to multiple surgical procedures.Thereafter, immunological assessment was performed, driving to the diagnosis of selective IgM deficiency.We propose a physiopathological relationship between this rare dysgammaglobulinemia and such fulminant staphylococcal invasive infection; that would, perhaps, justify humoral immunity assessment in patients undergoing staphylococcemia.